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・ Eien no Tsubasa
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・ Eien Pressure
・ Eien Yori Nagaku/Drive me crazy
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・ EIF
・ EIF-2 kinase
EIF-W2 protein domain
・ EIF1
・ EIF1AX
・ EIF1AY
・ EIF1B
・ EIF2
・ EIF2A
・ EIF2AK1
・ EIF2AK3
・ EIF2AK4
・ EIF2B
・ EIF2B1
・ EIF2B2
・ EIF2B3
・ EIF2B4


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EIF-W2 protein domain : ウィキペディア英語版
EIF-W2 protein domain

In molecular biology, the protein domain eIF4-gamma/eIF5/eIF2-epsilon is a family of evolutionarily related proteins. This domain is found at the C-terminus of several translation Initiation factors. It was first detected at the very C-termini of the yeast protein GCD6, eIF-2B epsilon, and two other eukaryotic translation initiation factors, eIF-4 gamma and eIF-5 and it may be involved in the interaction of eIF-2B, eIF-4 gamma, and eIF-5 with eIF-2.〔
==Function==
In molecular biology, the eIF-W2 domain functions as the binding site for Mnk eIF4E kinase, an enzyme that phosphorylates eukaryotic initiation factor 4E (eIF4E). For eIF2B-epsilon, the W2 C-terminal domain functions in guanine nucleotide exchange on eIF2. For eIF5, the W2 domain functions in mediating the multifactor complex (MFC) formation with eIF1, eIF2-GTP, eIF3 and Met-tRNAiMet. The eIF5 W2 C-terminal domain and the adjacent N-terminal linker region is responsible for the GDI activity against eIF2-GDP.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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